منابع مشابه
Pharmacokinetics in the elderly.
Animals undergo substantial changes in many physiologic and biochemical functions as a natural consequence of aging. In the absence of disease or other pathologic conditions, these changes occur in a gradual manner with time (generally expressed as a fractional or percentage change in that function per year or decade). Furthermore, for any given function and at any given chronologic age, there ...
متن کاملPharmacokinetics and pharmacodynamics in the elderly.
drug–drug interactions and adverse drug effects compared with younger patients makes use of pharmacologic agents in the elderly much more difficult. Usually, elderly is defined by a chronological age of 65 years or older. One should be aware of the great variability in pharmacokinetics and pharmacodynamics in the elderly. The variability seen in younger persons is much i...
متن کاملPharmacokinetics of fentanyl in the elderly.
The pharmacokinetics of fentanyl were determined in seven elderly (71-82 yr) and seven younger adults (18-41 yr) anaesthetized with thiopentone, nitrous oxide in oxygen and morphine. Fentanyl was administered as a 2-min i.v. infusion at doses of 15 micrograms kg-1 for elderly patients and 20 micrograms kg-1 for the younger patients. Plasma samples were obtained for 4 h and fentanyl concentratio...
متن کاملPharmacodynamics and pharmacokinetics in the elderly.
The paper deals with changes in pharmacodynamics (the study of what the drug does to the body) and pharmacokinetics (the study of what the body does to the drug) in the elderly. Elderly population takes 25–30 per cent of drugs taken by total population. In the elderly pharmacodynamics and pharmacokinetics are altered. According to pharmacokinetics, gastric juice pH is elevated which influences ...
متن کاملPharmacokinetics of ceftazidime in elderly volunteers.
The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in six elderly volunteers and 12 young subjects. Serum and urine samples were collected in serial order for 24 h and assayed by high-pressure liquid chromatography. The ceftazidime renal clearance was reduced in elderly subjects, a symptom related to normal aging of the kidneys. The decrease in volume of distribution in the...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1984
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1984.tb02454.x